Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Abstract Dipeptidyl peptidase-4 (DPP4) is a widely expressed enzyme transducing actions
through an anchored transmembrane molecule and a soluble circulating protein. Both …

Aims Dapagliflozin, a highly selective inhibitor of sodium‐glucose cotransporter 2 (SGLT2),
reduces hyperglycaemia and weight in patients with type 2 diabetes mellitus (T2DM) by …

Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1)
are the two primary incretin hormones secreted from the intestine on ingestion of various …

Aims Dapagliflozin, a selective sodium‐glucose cotransporter 2 (SGLT2) inhibitor, reduces
hyperglycaemia in patients with type 2 diabetes (T2DM) by increasing urinary glucose …

Increased fracture risk, traditionally associated with type 1 diabetes, has lately been of great
concern in patients with type 2 diabetes. A variable increase in fracture risk has been …

Summary Dipeptidyl peptidase-4 (DPP-4) controls glucose homeostasis through enzymatic
termination of incretin action. We report that plasma DPP-4 activity correlates with body …

Persons with type 1 or type 2 diabetes have a significantly higher fracture risk than age‐
matched persons without diabetes, attributed to disease‐specific deficits in the …

Objective The use of thiazolidinediones (TZDs) as insulin sensitizers has been shown to
have side effects including increased accumulation of bone marrow adipocytes (BMAds) …