Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …

Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …

Introduction In vivo imaging provides a window into the spatially complex, rapidly evolving
physiology of the cell that structural imaging alone cannot. However, observing this …

INTRODUCTION The human body is a crowded place. This crowding is even more acute
when the regulation of cell growth and proliferation fails during the formation of a tumor …

The cellular hallmarks of Parkinson's disease (PD) are the loss of nigral dopaminergic
neurons and the formation of α-synuclein-enriched Lewy bodies and Lewy neurites in the …

The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …

Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown
mechanism. Bax has been recently reported to be an integral membrane protein associated …

INTRODUCTION Our textbook understanding of the nanoscale organization of the cell and
its relationship to the thousands of proteins that drive cellular metabolism comes largely from …

The nuclear envelope defines the barrier between the nucleus and cytoplasm and features
inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear …

The nuclear lamina is a protein meshwork lining the nucleoplasmic face of the inner nuclear
membrane and represents an important determinant of interphase nuclear architecture. Its …