Structure and function of haemoglobins

DA Gell - Blood Cells, Molecules, and Diseases, 2018‏ - Elsevier
Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

The diversity of microbial responses to nitric oxide and agents of nitrosative stress: close cousins but not identical twins

LAH Bowman, S McLean, RK Poole… - Advances in microbial …, 2011‏ - Elsevier
Nitric oxide and related nitrogen species (reactive nitrogen species) now occupy a central
position in contemporary medicine, physiology, biochemistry, and microbiology. In particular …

Bacterial and archaeal globins—A revised perspective

SN Vinogradov, M Tinajero-Trejo, RK Poole… - … et Biophysica Acta (BBA …, 2013‏ - Elsevier
A bioinformatics survey of putative globins in over 2200 bacterial and some 140 archaeal
genomes revealed that over half the bacterial and approximately one fifth of archaeal …

Bacterial nitric oxide metabolism: Recent insights in rhizobia

A Salas, JJ Cabrera, A Jiménez-Leiva, S Mesa… - Advances in Microbial …, 2021‏ - Elsevier
Nitric oxide (NO) is a reactive gaseous molecule that has several functions in biological
systems depending on its concentration. At low concentrations, NO acts as a signaling …

Strategies of pathogens to escape from NO-based host defense

G De Simone, A di Masi, P Ascenzi - Antioxidants, 2022‏ - mdpi.com
Nitric oxide (NO) is an essential signaling molecule present in most living organisms
including bacteria, fungi, plants, and animals. NO participates in a wide range of biological …

Evolutionary and functional relationships in the truncated hemoglobin family

JP Bustamante, L Radusky, L Boechi… - PLoS computational …, 2016‏ - journals.plos.org
Predicting function from sequence is an important goal in current biological research, and
although, broad functional assignment is possible when a protein is assigned to a family …

Truncated (2/2) hemoglobin: Unconventional structures and functional roles in vivo and in human pathogenesis

M Nardini, A Pesce, M Bolognesi - Molecular Aspects of Medicine, 2022‏ - Elsevier
Truncated hemoglobins (trHbs) build a sub-class of the globin family, found in eubacteria,
cyanobacteria, unicellular eukaryotes, and in higher plants; among these, selected human …

Protein fold and structure in the truncated (2/2) globin family

M Nardini, A Pesce, M Milani, M Bolognesi - Gene, 2007‏ - Elsevier
Analysis of amino acids sequences and protein folds has recently unraveled the structural
bases and details of several proteins from the recently discovered “truncated hemoglobin” …

Diastereo-and Enantioselective Chemoenzymatic Synthesis of Chiral Tricyclic Intermediate of Anti-HIV Drug Lenacapavir

W Fu, A Liu, Y Yang - ACS Catalysis, 2025‏ - ACS Publications
Despite its great potential, the development and implementation of scalable new-to-nature
biocatalytic transformations in the chemoenzymatic synthesis of clinically significant …

Structural and functional properties of a truncated hemoglobin from a food-borne pathogen Campylobacter jejuni

C Lu, T Egawa, LM Wainwright, RK Poole… - Journal of Biological …, 2007‏ - ASBMB
Campylobacter jejuni contains two hemoglobins, Cgb and Ctb. Cgb has been suggested to
perform an NO detoxification reaction to protect the bacterium against NO attack. On the …