Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

A census of human RNA-binding proteins

S Gerstberger, M Hafner, T Tuschl - Nature Reviews Genetics, 2014 - nature.com
Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …

N6-methyladenosine-dependent regulation of messenger RNA stability

X Wang, Z Lu, A Gomez, GC Hon, Y Yue, D Han, Y Fu… - Nature, 2014 - nature.com
Abstract N 6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification
present in the messenger RNA of all higher eukaryotes,. Although essential to cell viability …

m6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program

S Zhang, BS Zhao, A Zhou, K Lin, S Zheng, Z Lu… - Cancer cell, 2017 - cell.com
The dynamic and reversible N 6-methyladenosine (m 6 A) RNA modification installed and
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

XL **, BF Sun, LU Wang, W **ao, X Yang, WJ Wang… - Cell research, 2014 - nature.com
Abstract The methyltransferase like 3 (METTL3)-containing methyltransferase complex
catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; …

Gene expression regulation mediated through reversible m6A RNA methylation

Y Fu, D Dominissini, G Rechavi, C He - Nature Reviews Genetics, 2014 - nature.com
Cellular RNAs carry diverse chemical modifications that used to be regarded as static and
having minor roles in'fine-tuning'structural and functional properties of RNAs. In this Review …

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

X Chen, A Li, BF Sun, Y Yang, YN Han, X Yuan… - Nature cell …, 2019 - nature.com
Abstract Although 5-methylcytosine (m5C) is a widespread modification in RNAs, its
regulation and biological role in pathological conditions (such as cancer) remain unknown …

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

AE Pasquinelli - Nature Reviews Genetics, 2012 - nature.com
MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways.
These small non-coding RNAs bind to target sequences in mRNAs, typically resulting in …

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

K Abdelmohsen, AC Panda, R Munk… - RNA biology, 2017 - Taylor & Francis
HuR influences gene expression programs and hence cellular phenotypes by binding to
hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular …

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

Y Wang, Y Li, JI Toth, MD Petroski, Z Zhang… - Nature cell …, 2014 - nature.com
Abstract N 6-methyladenosine (m6A) has been identified as the most abundant internal
modification of messenger RNA in eukaryotes. m6A modification is involved in cell fate …