For a long time, apoptosis was considered the sole form of programmed cell death during
development, homeostasis and disease, whereas necrosis was regarded as an unregulated …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

The consequences of DNA damage depend on the cell type and the severity of the damage.
Mild DNA damage can be repaired with or without cell-cycle arrest. More severe and …

Abstract Poly (ADP-ribose) polymerases (PARPs) are involved in the regulation of many
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …

Mammalian poly (ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear chromatin-
associated protein and belongs to a large family of enzymes that catalyzes the transfer of …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Patients with diabetes exhibit a high incidence of diabetic cardiomyopathy and vascular
complications, which underlie the development of retinopathy, nephropathy, and neuropathy …

Falciparum malaria is a complex disease with no simple explanation, affecting organs where
the parasite is rare as well as those organs where it is more common. We continue to argue …

Abstract Poly (ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear enzyme involved
in DNA repair. The therapeutic efficacy of drugs that inhibit PARP-1 in various disorders …