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Fibroblast growth factor in diabetic foot ulcer: progress and therapeutic prospects
Y Liu, Y Liu, J Deng, W Li, X Nie - Frontiers in endocrinology, 2021 - frontiersin.org
Diabetic foot ulcer (DFU) is a combination of neuropathy and various degrees of peripheral
vasculopathy in diabetic patients resulting in lower extremity infection, ulcer formation, and …
vasculopathy in diabetic patients resulting in lower extremity infection, ulcer formation, and …
Developmental pathways in the pathogenesis of lung fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
The fibroblast growth factor signaling pathway
DM Ornitz, N Itoh - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
L Wollin, E Wex, A Pautsch… - European …, 2015 - publications.ersnet.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease
characterised by fibrosis of the lung parenchyma and loss of lung function. Although the …
characterised by fibrosis of the lung parenchyma and loss of lung function. Although the …
The FGF family: biology, pathophysiology and therapy
A Beenken, M Mohammadi - Nature reviews Drug discovery, 2009 - nature.com
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …
processes, including brain patterning, branching morphogenesis and limb development …
[HTML][HTML] Fibroblast growth factor receptors (FGFRs) and noncanonical partners in cancer signaling
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is
context-dependent and is influenced by a complex crosstalk between signaling pathways …
context-dependent and is influenced by a complex crosstalk between signaling pathways …
[HTML][HTML] Receptor specificity of the fibroblast growth factor family: the complete mammalian FGF family
In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and
activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The …
activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The …
FGF family: from drug development to clinical application
Q Hui, Z **, X Li, C Liu, X Wang - International journal of molecular …, 2018 - mdpi.com
Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use
paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological …
paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological …
Genetic insights into the mechanisms of Fgf signaling
JR Brewer, P Mazot, P Soriano - Genes & development, 2016 - genesdev.cshlp.org
The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required
throughout embryonic and postnatal development and also regulates multiple homeostatic …
throughout embryonic and postnatal development and also regulates multiple homeostatic …
Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach
Originally characterized as angiogenic factors, fibroblast growth factors (FGFs) are
pleiotropic factors that exert autocrine and paracrine functions on tumor and stromal cells …
pleiotropic factors that exert autocrine and paracrine functions on tumor and stromal cells …