Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm
function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts …

Background Huntington's disease is an autosomal-dominant neurodegenerative disease
caused by CAG trinucleotide repeat expansion in HTT, resulting in a mutant huntingtin …

Huntington's disease is an autosomal-dominant, progressive neurodegenerative disorder
with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline …

Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

We have identified a novel gene containing CAG repeats and mapped it to chromosome
14q32. 1, the genetic locus for Machado-Joseph disease (MJD). In normal individuals the …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

More than 40 diseases, most of which primarily affect the nervous system, are caused by
expansions of simple sequence repeats dispersed throughout the human genome …

Microtubule associated protein tau is abnormally phosphorylated in Alzheimer's disease
(AD) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs). We …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …