It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

Increases in intracellular free Ca 2+ play a major role in many cellular processes. The
deregulation of Ca 2+ signaling is a feature of a variety of diseases, and modulators of Ca …

Purpose: We generated a humanized antibody, HuLuc63, which specifically targets CS1
(CCND3 subset 1, CRACC, and SLAMF7), a cell surface glycoprotein not previously …

Activation in transformed cells of normal stem cells' self-renewal pathways might contribute
to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 …

Background Improved clinical predictors for disease progression are needed for localised
prostate cancer, since only a subset of patients develop recurrent or refractory disease after …

Ion channels are important therapeutic targets due to their plethoric involvement in
physiological and pathological consequences. The transient receptor potential cation …

One of the major problems in management of prostate cancer is the lack of reliable genetic
markers predicting the clinical course of the disease. We analyzed expression profiles of …

BACKGROUND AND PURPOSE Cannabinoid receptor activation induces prostate
carcinoma cell (PCC) apoptosis, but cannabinoids other than Δ9‐tetrahydrocannabinol …

Rationale: Many of the interstitial lung diseases represent a diagnostic and therapeutic
challenge because their clinical and even histologic features are often nonspecific …