Gastro-oesophageal reflux disease (GERD) is a common disorder in adults and children.
The global prevalence of GERD is high and increasing. Non-erosive reflux disease is the …

Background High‐resolution manometry (HRM) has resulted in new revelations regarding
the pathophysiology of gastro‐esophageal reflux disease (GERD). The impact of new HRM …

OBJECTIVES A globally acceptable definition and classification of gastroesophageal reflux
disease (GERD) is desirable for research and clinical practice. The aim of this initiative was …

Background Gastroesophageal reflux disease (GERD) is one of the most frequent benign
disorders of the upper gastrointestinal tract. Management of GERD has always been …

Approximately a third of patients with suspected gastro-oesophageal reflux disease are
resistant or partial responders to proton pump inhibitors (PPIs). Many of these patients do …

Objective The aim of this paper is to shed light on the pathogenesis and pathophysiological
mechanisms underlying the development of hoarseness related to laryngopharyngeal reflux …

Patients with gastro-oesophageal reflux disease (GORD) who are not responding to proton
pump inhibitors (PPIs) given once daily are very common. Various underlying mechanisms …

RESULTS One hundred fifty patients were included, 102 women (mean age 52±14 yr, range
16–84). Among the 79 patients off PPI, five did not report any symptom during the recording …

Proton‐pump inhibitor failure has become a common clinical dilemma in gastrointestinal
clinics and has been increasingly encountered at the primary care level as well. Underlying …

Investigations and technical advances have enhanced our understanding and management
of gastroesophageal reflux disease. The recognition of the prevalence and importance of …