Epigenetic Reprogramming in Mice and Humans: From Fertilization to Primordial Germ Cell Development
In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …
to the development of primordial germline cells in a mouse and human embryo are …
A signal processing and deep learning framework for methylation detection using Oxford Nanopore sequencing
Oxford Nanopore sequencing can detect DNA methylations from ionic current signal of
single molecules, offering a unique advantage over conventional methods. Additionally …
single molecules, offering a unique advantage over conventional methods. Additionally …
Epigenetic and metabolic reprogramming in inflammatory bowel diseases: diagnostic and prognostic biomarkers in colorectal cancer
Background and aim" Inflammatory bowel disease"(IBD) is a chronic, relapsing inflammatory
disease of the intestinal tract that typically begins at a young age and might transit to …
disease of the intestinal tract that typically begins at a young age and might transit to …
[HTML][HTML] Parent-of-origin detection and chromosome-scale haploty** using long-read DNA methylation sequencing and Strand-seq
Hundreds of loci in human genomes have alleles that are methylated differentially according
to their parent of origin. These imprinted loci generally show little variation across tissues …
to their parent of origin. These imprinted loci generally show little variation across tissues …
Chromosome-level, nanopore-only genome and allele-specific DNA methylation of Pallas's cat, Otocolobus manul
Pallas's cat, or the manul cat (Otocolobus manul), is a small felid native to the grasslands
and steppes of central Asia. Population strongholds in Mongolia and China face growing …
and steppes of central Asia. Population strongholds in Mongolia and China face growing …
Detection of DNA methylation signatures through the lens of genomic imprinting
JN Hubert, N Iannuccelli, C Cabau, E Jacomet… - Scientific Reports, 2024 - nature.com
Genomic imprinting represents an original model of epigenetic regulation resulting in a
parent-of-origin expression. Despite the critical role of imprinted genes in mammalian …
parent-of-origin expression. Despite the critical role of imprinted genes in mammalian …
Prenatal environmental stressors and DNA methylation levels in placenta and peripheral tissues of mothers and neonates evaluated by applying artificial neural …
Exposure to environmental stressors during pregnancy plays an important role in influencing
subsequent susceptibility to certain chronic diseases through the modulation of epigenetic …
subsequent susceptibility to certain chronic diseases through the modulation of epigenetic …
Rapid human oogonia-like cell specification via transcription factor-directed differentiation
The generation of germline cells from human induced pluripotent stem cells (hiPSCs)
represents a milestone toward in vitro gametogenesis. Methods to recapitulate germline …
represents a milestone toward in vitro gametogenesis. Methods to recapitulate germline …
Creation and validation of the first infinium DNA methylation array for the human imprintome
Background Differentially methylated imprint control regions (ICRs) regulate the monoallelic
expression of imprinted genes. Their epigenetic dysregulation by environmental exposures …
expression of imprinted genes. Their epigenetic dysregulation by environmental exposures …
Impact of air pollution from different sources on sperm DNA methylation
M Vozdova, S Kubickova, V Kopecka… - International Journal …, 2024 - Taylor & Francis
Environmental exposure is associated with increased incidence of respiratory and
cardiovascular diseases and reduced fertility. Exposure to air pollution can influence gene …
cardiovascular diseases and reduced fertility. Exposure to air pollution can influence gene …