Tissue-Specific Regulation of CFTR Gene Expression
C Blotas, C Férec, S Moisan - International Journal of Molecular Sciences, 2023 - mdpi.com
More than 2000 variations are described within the CFTR (Cystic Fibrosis Transmembrane
Regulator) gene and related to large clinical issues from cystic fibrosis to mono-organ …
Regulator) gene and related to large clinical issues from cystic fibrosis to mono-organ …
The CFTR gene and regulation of its expression
VA McCarthy, A Harris - Pediatric pulmonology, 2005 - Wiley Online Library
The cystic fibrosis transmembrane conductance regulator gene (CFTR) shows clear
temporal and developmental regulation of its expression. However, there are few well …
temporal and developmental regulation of its expression. However, there are few well …
The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications
The resistin gene is a potential candidate for the etiology of insulin resistance and type 2
diabetes and has been implicated as the molecular link between type 2 diabetes and …
diabetes and has been implicated as the molecular link between type 2 diabetes and …
Intronic enhancers coordinate epithelial-specific loo** of the active CFTR locus
CJ Ott, NP Blackledge, JL Kerschner… - Proceedings of the …, 2009 - National Acad Sciences
The regulated expression of large human genes can depend on long-range interactions to
establish appropriate three-dimensional structures across the locus. The cystic fibrosis …
establish appropriate three-dimensional structures across the locus. The cystic fibrosis …
Cellular heterogeneity in the 16HBE14o− airway epithelial line impacts biological readouts
The airway epithelial cell line, 16HBE14o−, is an important cell model for studying airway
disease. 16HBE14o− cells were originally generated from primary human bronchial …
disease. 16HBE14o− cells were originally generated from primary human bronchial …
Oxidative Stress Regulates CFTR Gene Expression in Human Airway Epithelial Cells through a Distal Antioxidant Response Element
Cystic fibrosis transmembrane conductance regulator gene (CFTR) expression in human
airway epithelial cells involves the recruitment of distal cis-regulatory elements, which are …
airway epithelial cells involves the recruitment of distal cis-regulatory elements, which are …
A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter
CJ Ott, M Suszko, NP Blackledge… - Journal of cellular …, 2009 - Wiley Online Library
Genes can maintain spatiotemporal expression patterns by long‐range interactions between
cis‐acting elements. The cystic fibrosis transmembrane conductance regulator gene (CFTR) …
cis‐acting elements. The cystic fibrosis transmembrane conductance regulator gene (CFTR) …
Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells
The forkhead box A transcription factors, FOXA1 and FOXA2, function as pioneer factors to
open condensed chromatin and facilitate binding of other proteins. We showed previously …
open condensed chromatin and facilitate binding of other proteins. We showed previously …
Transcriptional networks driving enhancer function in the CFTR gene
JL Kerschner, A Harris - Biochemical Journal, 2012 - portlandpress.com
A critical cis-regulatory element for the CFTR (cystic fibrosis transmembrane conductance
regulator) gene is located in intron 11, 100 kb distal to the promoter, with which it interacts …
regulator) gene is located in intron 11, 100 kb distal to the promoter, with which it interacts …
Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region
H Swahn, J Sabith Ebron, KM Lamar… - Journal of Cellular …, 2019 - Wiley Online Library
Abstract E74‐like factor 5 (ELF5) and ETS‐homologous factor (EHF) are epithelial selective
ETS family transcription factors (TFs) encoded by genes at chr11p13, a region associated …
ETS family transcription factors (TFs) encoded by genes at chr11p13, a region associated …