JAK inhibitors in the treatment of atopic dermatitis

R Chovatiya, AS Paller - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with heterogenous
presentation and often immense patient burden. Safe, targeted treatment options are …

JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review

IH Huang, WH Chung, PC Wu, CB Chen - Frontiers in immunology, 2022 - frontiersin.org
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …

Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind …

S Danese, S Vermeire, W Zhou, AL Pangan… - The lancet, 2022 - thelancet.com
Background There is a great unmet need for advanced therapies that provide rapid, robust,
and sustained disease control for patients with ulcerative colitis. We assessed the efficacy …

European guideline (EuroGuiDerm) on atopic eczema: part I–systemic therapy

A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …

Efficacy and safety of upadacitinib vs dupilumab in adults with moderate-to-severe atopic dermatitis: a randomized clinical trial

A Blauvelt, HD Teixeira, EL Simpson… - JAMA …, 2021 - jamanetwork.com
Importance Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an
unmet need for treatments that provide rapid and high levels of skin clearance and itch …

European guideline (EuroGuiDerm) on atopic eczema–part II: non‐systemic treatments and treatment recommendations for special AE patient populations

A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …

Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from …

K Reich, HD Teixeira, M de Bruin-Weller, T Bieber… - The Lancet, 2021 - thelancet.com
Background Systemic therapies are typically combined with topical corticosteroids for the
management of moderate-to-severe atopic dermatitis. Upadacitinib is an oral Janus kinase …

A review on the safety of using JAK inhibitors in dermatology: clinical and laboratory monitoring

C Samuel, H Cornman, A Kambala… - Dermatology and Therapy, 2023 - Springer
Janus kinase (JAK) inhibitors are disease-modifying agents with efficacy in treating a
spectrum of burdensome dermatologic conditions. The US Food and Drug Administration …

Systemic immunomodulatory treatments for atopic dermatitis: update of a living systematic review and network meta-analysis

AM Drucker, DE Morra, D Prieto-Merino… - JAMA …, 2022 - jamanetwork.com
Importance Systemic treatments for atopic dermatitis are being evaluated primarily in
placebo-controlled trials; network meta-analysis can provide relative efficacy and safety …

Safety profile of upadacitinib over 15 000 patient-years across rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and atopic dermatitis

GR Burmester, SB Cohen, KL Winthrop, P Nash… - RMD open, 2023 - rmdopen.bmj.com
Objective To evaluate the long-term safety profile for upadacitinib across rheumatoid arthritis
(RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS) and atopic dermatitis (AD) …