An update on vitamin D metabolism

F Saponaro, A Saba, R Zucchi - International journal of molecular …, 2020‏ - mdpi.com
Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone
homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been …

Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue …

P Lips, KD Cashman, C Lamberg-Allardt… - European journal of …, 2019‏ - academic.oup.com
Vitamin D deficiency (serum 25-hydroxyvitamin D (25 (OH) D)< 50 nmol/L or 20 ng/mL) is
common in Europe and the Middle East. It occurs in< 20% of the population in Northern …

New aspects of vitamin D metabolism and action—Addressing the skin as source and target

D Bikle, S Christakos - Nature Reviews Endocrinology, 2020‏ - nature.com
Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …

[HTML][HTML] Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

JA Revez, T Lin, Z Qiao, A Xue, Y Holtz, Z Zhu… - Nature …, 2020‏ - nature.com
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a
genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 …

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016‏ - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Genome-wide patterns of selection in 230 ancient Eurasians

I Mathieson, I Lazaridis, N Rohland, S Mallick… - Nature, 2015‏ - nature.com
Ancient DNA makes it possible to observe natural selection directly by analysing samples
from populations before, during and after adaptation events. Here we report a genome-wide …

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

X Jiang, PF O'Reilly, H Aschard, YH Hsu… - Nature …, 2018‏ - nature.com
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and
diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four …

Vitamin D for health: a global perspective

A Hossein-nezhad, MF Holick - Mayo clinic proceedings, 2013‏ - Elsevier
It is now generally accepted that vitamin D deficiency is a worldwide health problem that
affects not only musculoskeletal health but also a wide range of acute and chronic diseases …

Vitamin D and cardiovascular disease prevention

S Pilz, N Verheyen, MR Grübler, A Tomaschitz… - Nature Reviews …, 2016‏ - nature.com
Vitamin D is a precursor of the steroid hormone calcitriol that is crucial for bone and mineral
metabolism. Both the high prevalence of vitamin D deficiency in the general population and …

Vitamin D as an early predictor of multiple sclerosis activity and progression

A Ascherio, KL Munger, R White, K Köchert… - JAMA …, 2014‏ - jamanetwork.com
Importance It remains unclear whether vitamin D insufficiency, which is common in
individuals with multiple sclerosis (MS), has an adverse effect on MS outcomes. Objectives …