The recent outbreak of coronavirus disease 2019 (COVID‐19), caused by the Severe Acute
Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) has resulted in a world‐wide …

In the post rotavirus vaccine era, norovirus (NoV) plays an increasingly important role in
epidemic and sporadic gastroenteritis among children. This study was designed to provide …

Fever is a common symptom of influenza and coronavirus disease 2019 (COVID-19), yet its
physiological role in host resistance to viral infection remains less clear. Here, we …

Human noroviruses (HuNoVs) are the leading cause of epidemic and sporadic acute
gastroenteritis worldwide. We previously demonstrated human intestinal stem cell-derived …

Human intestinal tissue–derived enteroids (HIEs; also called organoids) are a powerful ex
vivo model for gastrointestinal research. Genetic modification of these nontransformed …

Noroviruses, in the genus Norovirus, are a significant cause of viral gastroenteritis in
humans and animals. For almost 50 years, the lack of a cultivation system for human …

Infectious diseases affect individual health and have widespread societal impacts. New ex
vivo models are critical to understand pathogenesis, host response, and features necessary …

Globally, most cases of gastroenteritis are caused by pandemic GII. 4 human norovirus
(HuNoV) strains with no approved therapies or vaccines available. The cellular pathways …

The presence of microbes in the colon impacts host physiology. Therefore, microbes are
being evaluated as potential treatments for colorectal diseases. Humanized model systems …

Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis worldwide; yet
currently, no vaccines or FDA-approved antiviral drugs are available to counter these …