Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …

One of the most important problems in development is how epigenetic domains can first be
established, and then maintained, within cells. To address this question, we propose a …

We develop a predictive theoretical model of the physical mechanisms that govern the
heritability and maintenance of epigenetic modifications. This model focuses on a particular …

Dimension reduction is a challenging problem in complex dynamical systems. Here, a
dimension reduction approach of landscape (DRL) for complex dynamical systems is …

During development, progenitors often differentiate many cell generations after receiving
signals. These delays must be robust yet tunable for precise population size control …

Genomic regions can acquire heritable epigenetic states through unique histone
modifications, which lead to stable gene expression patterns without altering the underlying …

Dysregulation of gene expression, often interpreted by gene transcription as an endpoint
response, is tightly associated with human cancer. Long noncoding RNAs (lncRNAs) …

Compact chromatin is closely linked with gene silencing in part by sterically masking access
to promoters, inhibiting transcription factor binding and preventing polymerase from …

The transition between epithelial and mesenchymal (EMT) is a fundamental cellular process
that plays critical roles in development, cancer metastasis, and tissue wound healing. EMT is …