S phase kinase-associated protein 1 (SKP1)–cullin 1 (CUL1)–F-box protein (SCF) ubiquitin
ligase complexes use a family of F-box proteins as substrate adaptors to mediate the …

Cullin proteins are molecular scaffolds that have crucial roles in the post-translational
modification of cellular proteins involving ubiquitin. The mammalian cullin protein family …

The posttranslational addition of ubiquitin (Ub) helps control the half-life, localization, and
action of many intracellular plant proteins. A primary function is the degradation of …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

The proper regulation of apoptosis is essential for the survival of multicellular organisms.
Furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia …

The clinical successes of proteasome inhibitors for the treatment of cancer have highlighted
the therapeutic potential of targeting this protein degradation system. However, proteasome …

Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes,
and the identification of their substrates is critical to understanding regulation of the …

F-box proteins are the substrate binding subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin
ligase complexes. Using affinity purifications and mass spectrometry, we identified RRM2 …

Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the
timely and precise ubiquitin–proteasome-dependent degradation of key cell cycle proteins …

The ubiquitin-proteasome system (UPS) promotes the timely degradation of short-lived
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …