Advances in schistosomiasis drug discovery based on natural products.
Schistosomiasis is a neglected tropical disease affecting over 250 million people worldwide.
The disease is the second most prevalent neglected tropical disease after malaria …
The disease is the second most prevalent neglected tropical disease after malaria …
Unveiling potent inhibitors for schistosomiasis through ligand-based drug design, molecular docking, molecular dynamics simulations and pharmacokinetics …
Schistosomiasis is a neglected tropical disease which imposes a considerable and enduring
impact on affected regions, leading to persistent morbidity, hindering child development …
impact on affected regions, leading to persistent morbidity, hindering child development …
Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis
CM Azevedo, CS Meira, JW da Silva, DMN Moura… - Molecules, 2023 - mdpi.com
It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease
transmission is related to the poor sanitation and hygiene habits that affect residents of …
transmission is related to the poor sanitation and hygiene habits that affect residents of …
Computational insights into natural antischistosomal metabolites as SmHDAC8 inhibitors: molecular docking, ADMET profiling, and molecular dynamics simulation
AA Alzain, RM Mukhtar, N Abdelmoniem, FA Elbadwi… - Metabolites, 2023 - mdpi.com
Schistosomiasis is a neglected tropical disease with a significant socioeconomic impact. It is
caused by several species of blood trematodes from the genus Schistosoma, with S …
caused by several species of blood trematodes from the genus Schistosoma, with S …
Computer-aided discovery of novel SmDHODH inhibitors for schistosomiasis therapy: Ligand-based drug design, molecular docking, molecular dynamic simulations …
SC Ja'afaru, A Uzairu, S Hossain… - PLOS Neglected …, 2024 - journals.plos.org
Schistosomiasis, also known as bilharzia or snail fever, is a tropical parasitic disease
resulting from flatworms of the Schistosoma genus. This often overlooked disease has …
resulting from flatworms of the Schistosoma genus. This often overlooked disease has …
Using ChEMBL to complement schistosome drug discovery
G Padalino, A Coghlan, G Pagliuca, JE Forde-Thomas… - Pharmaceutics, 2023 - mdpi.com
Schistosomiasis is one of the most important neglected tropical diseases. Until an effective
vaccine is registered for use, the cornerstone of schistosomiasis control remains …
vaccine is registered for use, the cornerstone of schistosomiasis control remains …
Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica
Y Yang, XY Wang, C Duan, ZJ Wang, HY Sheng… - Scientific Reports, 2023 - nature.com
Schistosomiasis japonicum can cause different degrees of organ damage and complex
human immune pathological reactions, which often invade the intestine and liver. The …
human immune pathological reactions, which often invade the intestine and liver. The …
[HTML][HTML] Artificial intelligence systems for the design of magic shotgun drugs
JT Moreira-Filho, MFB da Silva, JVVB Borba… - Artificial Intelligence in …, 2023 - Elsevier
Designing magic shotgun compounds, ie, compounds hitting multiple targets using artificial
intelligence (AI) systems based on machine learning (ML) and deep learning (DL) …
intelligence (AI) systems based on machine learning (ML) and deep learning (DL) …
[HTML][HTML] In Vitro and In Vivo Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from Drimys brasiliensis Branches
In the present study, the hexane extract from branches of Drimys brasiliensis (Winteraceae)
displayed potent activity against Schistosoma mansoni parasites (100% mortality of the …
displayed potent activity against Schistosoma mansoni parasites (100% mortality of the …
A comprehensive exploration of schistosomiasis: Global impact, molecular characterization, drug discovery, artificial intelligence and future prospects
W Ekloh, A Asafu-Adjaye, CNL Tawiah-Mensah… - Heliyon, 2024 - cell.com
Schistosomiasis, one of the neglected tropical diseases which affects both humans and
animals, is caused by trematode worms of the genus Schistosoma. The disease is caused …
animals, is caused by trematode worms of the genus Schistosoma. The disease is caused …