Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have
been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and …

During active tuberculosis a spectrum of physiologically different Mycobacterium
tuberculosis bacilli reside in human tissues. Subpopulations of the pathogen survive …

Apicomplexa are important pathogens that include the causative agents of malaria,
toxoplasmosis, and cryptosporidiosis. Apicomplexan parasites contain a relict chloroplast …

Antimicrobial drug resistance is an urgent problem in the control and treatment of many of
the world's most serious infections, including Plasmodium falciparum malaria, tuberculosis …

To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

Mycobacterium tuberculosis (Mtb) requires protein secretion systems like ESX-1 for
intracellular survival and virulence. The major virulence determinant and ESX-1 substrate …

Isoprenoids are the output of the polymerization of five-carbon, branched isoprenic chains
derived from isopentenyl pyrophosphate (IPP) and its isomer, dimethylallyl pyrophosphate …

Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the
causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2 C-methyl …

Isoprenoids, a diverse class of natural products, are present in all living organisms. Their two
universal building blocks are synthesized via two independent pathways: the mevalonate …