Both ageing and chronic stress are associated with altered brain plasticity, dysregulation of
the immune system, and an increased risk of develo** brain disorders; all of which have …

The brain responds differently to environmental and internal signals that relate to the stage
of development of neural systems. While genetic and epigenetic factors contribute to a …

Light therapy improves multiple conditions such as seasonal affective disorders, circadian
rhythm dysregulations, and neurodegenerative diseases. However, little is known about its …

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of
molecular biology and the new tools derived from molecular genetics have revolutionized …

To date, our understanding of the Substance P (SP) and neurokinin 1 receptor (NK1R)
system shows intricate relations between human physiology and disease occurrence or …

Netupitant is a new, selective NK1 receptor antagonist under development for the prevention
of chemotherapy‐induced nausea and vomiting. Two studies were conducted to evaluate …

Exercise-induced bronchoconstriction (EIB) is a common complication of athletes and
individuals who exercise regularly. It is estimated that about 90% of patients with underlying …

The type 1 neurokinin receptor (NK1R) antagonist aprepitant and its iv prodrug fosaprepitant
have been approved for prevention of acute and delayed nausea and vomiting associated …

The brain serotonergic system is colocalized and interacts with the neuropeptidergic
substance P/neurokinin-1 (SP/NK1) system. Both these neurochemical systems have …

BACKGROUND: Animal studies demonstrate that stress and negative affect enhance the
release of the neuropeptide substance P (SP), which binds to the neurokinin 1 (NK1) …