During carcinogenesis, advanced tumors are surrounded by both stromal and immune cells,
which support tumor development. In addition, inflammation and angiogenesis are …

Canine mammary tumors (CMTs) are the most common neoplasm in intact female dogs.
Canine mammary cancer (CMC) represents 50% of CMTs, and besides surgery, which is the …

Focal adhesion kinase (FAK), also known as protein tyrosine kinase 2 (PTK2), is a
ubiquitously expressed non-receptor tyrosine kinase, that plays a pivotal role in integrin …

Neovascularization is a key factor that contributes to tumor metastasis, and vasculogenic
mimicry (VM) is an important form of neovascularization found in highly invasive tumors …

Background Gastric cancer (GC) is one of the most lethal malignant tumors worldwide with
poor outcomes. Vascular mimicry (VM) is an alternative blood supply to tumors that is …

Hepatocellular carcinoma (HCC) is a typical hyper-vascular solid tumor; aberrantly rich in
tumor vascular network contributes to its malignancy. Conventional anti-angiogenic …

Abstract Type IIA topoisomerase (TOP2A) is significantly associated with malignant tumor
development, invasion, treatment and its prognosis, and has been shown to be a therapeutic …

Background: Cancer-associated fibroblast (CAF) exosomal miRNAs have gradually a hot
spot in cancer therapy. This study mainly explores the effect of CAF-derived exosomal miR …

Background: Chemotherapy for non-small-cell lung cancer (NSCLC) still leads to
unsatisfactory clinical prognosis because of poor active targeting and tumor metastasis …

Malignant tumors represent some of the most intractable diseases that endanger human
health. A glioma is a tumor of the central nervous system that is characterized by severe …