Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Much evidence shows that physical exercise (PE) is a strong gene modulator that induces
structural and functional changes in the brain, determining enormous benefit on both …

BACKGROUND: Major depression occurs in 4.4% to 20% of the general population. Studies
suggest that major depression is accompanied by immune dysregulation and activation of …

A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …

The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …

BACKGROUND: Transcranial direct current stimulation (tDCS) is a neuromodulatory
technique that delivers low-intensity, direct current to cortical areas facilitating or inhibiting …

Consistent evidence indicates that exercise improves cognition and mood, with preliminary
evidence suggesting that brain-derived neurotrophic factor (BDNF) may mediate these …

Leading biological hypotheses propose that biological changes may underlie major
depressive disorder onset and relapse/recurrence. Here, we investigate if there is …

We systematically reviewed 12 epidemiological studies to determine whether an association
exists between diet quality and patterns and mental health in children and adolescents; 9 …