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Histone post-translational modifications—cause and consequence of genome function
Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
The molecular basis of heterochromatin assembly and epigenetic inheritance
SIS Grewal - Molecular cell, 2023 - cell.com
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …
silencing of repetitive DNA elements. Histone modifications are essential for the …
Chromatin compartmentalization regulates the response to DNA damage
The DNA damage response is essential to safeguard genome integrity. Although the
contribution of chromatin in DNA repair has been investigated,, the contribution of …
contribution of chromatin in DNA repair has been investigated,, the contribution of …
Liquid–liquid phase separation drives cellular function and dysfunction in cancer
Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …
The molecular principles of gene regulation by Polycomb repressive complexes
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Genome control by SMC complexes
C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
A framework for understanding the functions of biomolecular condensates across scales
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
Nuclear compartmentalization as a mechanism of quantitative control of gene expression
Gene regulation requires the dynamic coordination of hundreds of regulatory factors at
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
On the role of phase separation in the biogenesis of membraneless compartments
Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …
revealing their interactions in macromolecular complexes and inspiring strategies for …