Lipid nanoparticles for the posterior eye segment

L Bonilla, M Espina, P Severino, A Cano, M Ettcheto… - Pharmaceutics, 2021 - mdpi.com
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles,
Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for …

Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye–Part II-Ocular drug-loaded lipid nanoparticles

E Sánchez-López, M Espina, S Doktorovova… - European Journal of …, 2017 - Elsevier
In the recent decades, various controlled delivery systems have been introduced with the
aim to improve solubility, stability and bioavailability of poorly absorbed drugs. Among all …

Nanoemulsion as a feasible and biocompatible carrier for ocular delivery of travoprost: Improved pharmacokinetic/pharmacodynamic properties

A Ismail, M Nasr, O Sammour - International journal of pharmaceutics, 2020 - Elsevier
Travoprost is a synthetic prostaglandin F2α analogue used in treatment of glaucoma. Due to
its water insolubility and oily nature, novel delivery systems need to be developed to …

Nanotherapies for the treatment of ocular diseases

S Reimondez-Troitiño, N Csaba, MJ Alonso… - European Journal of …, 2015 - Elsevier
The topical route is the most frequent and preferred way to deliver drugs to the eye.
Unfortunately, the very low ocular drug bioavailability (less than 5%) associated with this …

Lipid-based nanocarriers for ophthalmic administration: towards experimental design implementation

FM González-Fernández, A Bianchera, P Gasco… - Pharmaceutics, 2021 - mdpi.com
Nanotherapeutics based on biocompatible lipid matrices allow for enhanced solubility of
poorly soluble compounds in the treatment of ophthalmic diseases, overcoming the …

Topical delivery of ocular therapeutics: carrier systems and physical methods

JG Souza, K Dias, TA Pereira… - Journal of Pharmacy …, 2014 - academic.oup.com
Objective The basic concepts, major mechanisms, technological developments and
advantages of the topical application of lipid-based systems (microemulsions …

Lipid-based nanocarriers challenging the ocular biological barriers: Current paradigm and future perspectives

KK Abla, MM Mehanna - Journal of Controlled Release, 2023 - Elsevier
Eye is the most specialized and sensory body organ and treating eye diseases efficiently is
necessary. Despite various attempts, the design of a consummate ophthalmic drug delivery …

Moxifloxacin loaded gelatin nanoparticles for ocular delivery: Formulation and in-vitro, in-vivo evaluation

A Mahor, SK Prajapati, A Verma, R Gupta… - Journal of colloid and …, 2016 - Elsevier
The current research focuses on develo** positively charged gelatin nanoparticles loaded
with moxifloxacin for its effective ocular delivery and controlled release in corneal eye layer …

Artificial neural network based particle size prediction of polymeric nanoparticles

J Youshia, ME Ali, A Lamprecht - European Journal of Pharmaceutics and …, 2017 - Elsevier
Particle size of nanoparticles and the respective polydispersity are key factors influencing
their biopharmaceutical behavior in a large variety of therapeutic applications. Predicting …

Triamcinolone acetonide loaded-cationic nano-lipoidal formulation for uveitis: Evidences of improved biopharmaceutical performance and anti-inflammatory activity

P Nirbhavane, G Sharma, B Singh, G Begum… - Colloids and Surfaces B …, 2020 - Elsevier
Topical administration of corticosteroids is the cornerstone treatment of anterior uveitis, but
poor corneal penetration and retention cause hindrance in their therapeutic utility. The …