Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …

Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …

Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …

The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …

Major depressive disorder (MDD) is the result of complex gene–environment interactions.
According to the World Health Organization, MDD is the leading cause of disability …

Bone tissue is continuously remodeled through the concerted actions of bone cells, which
include bone resorption by osteoclasts and bone formation by osteoblasts, whereas …

Osteocalcin is among the most abundant proteins in bone and is produced exclusively by
osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies …

Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic
exercise at the time levels of insulin decrease. In contrast, circulating levels of osteocalcin …

BACKGROUND Disorders of bone metabolism, most notably osteoporosis, are highly
prevalent and predispose to fractures, causing high patient morbidity and mortality …

The portrait of osteoblasts and osteocytes has been subjected to a revision, since a large
body of evidence is attributing these cells amazing roles both inside and outside the bone …