Opioid receptors have been targeted for the treatment of pain and related disorders for
thousands of years, and remain the most widely used analgesics in the clinic. Mu (μ), kappa …

The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Opioids are the most commonly used and effective analgesic treatments for severe pain, but
they have recently come under scrutiny owing to epidemic levels of abuse and overdose …

G‐protein‐coupled receptors (GPCRs) can form heteromeric complexes. Herein'we describe
a new approach to test the heteromerization of 2 receptors' or 2 receptor subunits' and to …

It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the
plasma membrane, but the cellular mechanism by which this occurs has remained unclear …

Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases …

The role of Gβγ subunits in cellular signaling has become well established in the past 20
years. Not only do they regulate effectors once thought to be the sole targets of Gα subunits …

Background and Purpose Cannabinoids are a promising therapeutic avenue for chronic
pain. However, clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition …