Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

Membrane traffic in eukaryotic cells is mediated by transport vesicles that bud from a
precursor compartment and are transported to their destination compartment where they …

Exosomes are secreted to the extracellular milieu when multivesicular endosomes (MVEs)
dock and fuse with the plasma membrane. However, MVEs are also known to fuse with …

Introduction The eukaryotic cell contains membrane-bound organelles with distinct
functionality and composition. Preservation of organelle identity depends on the highly …

COPI‐coated vesicles mediate transport between Golgi stacks and retrograde transport from
the Golgi to the endoplasmic reticulum. The COPI coat exists as a stable heptameric …

Glycosylation is a ubiquitous modification that occurs on proteins and lipids in all living cells.
Consistent with their high complexity, glycans play crucial biological roles in protein quality …

The exocyst is a conserved octameric complex that tethers exocytic vesicles to the plasma
membrane prior to fusion. Exocyst assembly and delivery mechanisms remain unclear …

The Golgi apparatus lies at the centre of the secretory pathway. It consists of a series of
flattened compartments typically organised into a stack that, in mammals, is connected to …

The conserved oligomeric Golgi (COG) complex, a multisubunit tethering complex of the
CATCHR (complexes associated with tethering containing helical rods) family, controls …

Glycosylation is a ubiquitous modification of lipids and proteins. Despite the essential
contribution of glycoconjugates to the viability of all living organisms, diseases of …