Phage display and other peptide display technologies

W Jaroszewicz, J Morcinek-Orłowska… - FEMS microbiology …, 2022 - academic.oup.com
Phage display technology, which is based on the presentation of peptide sequences on the
surface of bacteriophage virions, was developed over 30 years ago. Improvements in phage …

Phage display derived monoclonal antibodies: from bench to bedside

MA Alfaleh, HO Alsaab, AB Mahmoud… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Phage display based biosensing: Recent advances and challenges

M Wang, S Pang, H Zhang, Z Yang, A Liu - TrAC Trends in Analytical …, 2024 - Elsevier
Phage display enables to screen probes such as peptide, antibody and nanobody with high
specificity and affinity to the target, providing excellent probes for various analytical or …

[HTML][HTML] Basics of antibody phage display technology

L Ledsgaard, M Kilstrup, A Karatt-Vellatt, J McCafferty… - Toxins, 2018 - mdpi.com
Antibody discovery has become increasingly important in almost all areas of modern
medicine. Different antibody discovery approaches exist, but one that has gained increasing …

PDZ domains and their binding partners: structure, specificity, and modification

HJ Lee, JJ Zheng - Cell communication and Signaling, 2010 - Springer
PDZ domains are abundant protein interaction modules that often recognize short amino
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …

[HTML][HTML] Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

KN Lam, P Spanogiannopoulos, P Soto-Perez… - Cell Reports, 2021 - cell.com
Mechanistic insights into the role of the human microbiome in the predisposition to and
treatment of disease are limited by the lack of methods to precisely add or remove microbial …

Evolution of phage display libraries for therapeutic antibody discovery

Y Zhang - MAbs, 2023 - Taylor & Francis
Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most
important classes of biotherapeutics in recent decades. The success of mAb is due to their …

Filamentous phage display in the new millennium

JW Kehoe, BK Kay - Chemical reviews, 2005 - ACS Publications
Since its first description in 1985, publications involving phage display have relied upon the
fact that the displayed entity, be it a peptide, protein, or antibody fragment, is physically …

Phage display: practicalities and prospects

WGT Willats - Plant molecular biology, 2002 - Springer
Phage display is a molecular technique by which foreign proteins are expressed at the
surface of phage particles. Such phage thereby become vehicles for expression that not only …

Progress in phage display: evolution of the technique and its applications

T Bratkovič - Cellular and molecular life sciences, 2010 - Springer
Phage display, the presentation of (poly) peptides as fusions to capsid proteins on the
surface of bacterial viruses, celebrates its 25th birthday in 2010. The technique, coupled with …