Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia
Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available
medications. Thus, understanding the neural basis of these deficits is crucial for the …
medications. Thus, understanding the neural basis of these deficits is crucial for the …
Alterations in cortical interneurons and cognitive function in schizophrenia
Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …
Neurotransmitter deficits from frontotemporal lobar degeneration
Frontotemporal lobar degeneration causes a spectrum of complex degenerative disorders
including frontotemporal dementia, progressive supranuclear palsy and corticobasal …
including frontotemporal dementia, progressive supranuclear palsy and corticobasal …
Neuroimaging studies of GABA in schizophrenia: a systematic review with meta-analysis
A Egerton, G Modinos, D Ferrera, P McGuire - Translational psychiatry, 2017 - nature.com
Data from animal models and from postmortem studies suggest that schizophrenia is
associated with brain GABAergic dysfunction. The extent to which this is reflected in data …
associated with brain GABAergic dysfunction. The extent to which this is reflected in data …
Alterations of cortical GABA neurons and network oscillations in schizophrenia
The hypothesis that alterations of cortical inhibitory γ-aminobutyric acid (GABA) neurons are
a central element in the pathology of schizophrenia has emerged from a series of …
a central element in the pathology of schizophrenia has emerged from a series of …
Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies
Schizophrenia is a severe disorder that disrupts the function of multiple brain systems,
resulting in impaired social and occupational functioning. The etiology and pathogenesis of …
resulting in impaired social and occupational functioning. The etiology and pathogenesis of …
Human positron emission tomography neuroimaging
Neuroimaging with positron emission tomography (PET) is the most powerful tool for
understanding pharmacology, neurochemistry, and pathology in the living human brain. This …
understanding pharmacology, neurochemistry, and pathology in the living human brain. This …
Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome
Dysfunction of the γ-aminobutyric acid-ergic system in Tourette syndrome may conceivably
underlie the symptoms of motor disinhibition presenting as tics and psychiatric …
underlie the symptoms of motor disinhibition presenting as tics and psychiatric …
Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia
DW Volk, T Matsubara, S Li… - American Journal of …, 2012 - Am Psychiatric Assoc
Objective In schizophrenia, alterations within the prefrontal cortical GABA system appear to
be most prominent in neurons that contain parvalbumin or somatostatin but not calretinin …
be most prominent in neurons that contain parvalbumin or somatostatin but not calretinin …