Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

The inflammasome-mediated cleavage of gasdermin D (GSDMD) causes pyroptosis and
inflammatory cytokine release to control pathogen infection, but how pathogens evade this …

Mycobacterium tuberculosis (Mtb) is a very successful pathogen, strictly adapted to humans
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …

Mycobacterium tuberculosis PtpA is a secreted effector protein that dephosphorylates
several proteins in the host cell cytoplasm, such as p-JNK, p-p38, and p-VPS33B, leading to …

Signal transduction is an essential activity of all living cells. Broadly defined, signal
transduction is the sensing of a signal or input and its conversion into an output or response …

Reversible protein phosphorylation is a major regulation mechanism of fundamental
biological processes, not only in eukaryotes but also in bacteria. A growing body of evidence …

Bacterial pathogens interact with host membranes to trigger a wide range of cellular
processes during the course of infection. These processes include alterations to the …

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), evades the
antimicrobial defenses of the host and survives within the infected individual through a …

Bacterial infection is a highly complex biological process involving a dynamic interaction
between the invading microorganism and the host. Specifically, intracellular pathogens …