Polycystic kidney disease is typified by cysts in the kidney and extra-renal manifestations
including hypertension and heart failure. The main genetic underpinning this disease are …

The ability of cells to perceive and respond to mechanical cues is essential for numerous
biological activities. Emerging evidence indicates important contributions of organelles to …

Intracellular Ca2+ signaling is important in the regulation of several cellular processes
including autophagy. The endoplasmic reticulum (ER) is the main and largest intracellular …

The current differentiation process of human pluripotent stem cells (hPSCs) into
cardiomyocytes to enhance the purity of hPSC-derived cardiomyocytes requires some …

Macroautophagy/autophagy is an intracellular process involved in the breakdown of
macromolecules and organelles. Recent studies have shown that PKD2/PC2/TRPP2 …

HERP is an endoplasmic reticulum (ER) membrane protein and is strongly induced by stress
conditions. A recent study has indicated that HERP cooperates in apoptosis during …

Aims Considerable evidence points to critical roles of intracellular Ca 2+ homeostasis in the
modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain …

Inefficient differentiation and insufficient maturation are barriers to the application of human
pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) for research and therapy. Great …

Abstract Polycystin-2 (PC2), which is a transmembrane protein encoded by the PKD2 gene,
plays an important role in kidney disease, but its role in lipopolysaccharide (LPS)-induced …

Background Myocardial injury induced by refeeding syndrome (RFS) is one of the important
causes of deterioration in critically ill patients. Sirtuin-3 (SIRT3) has been shown to regulate …