Background: Chagas disease, resulting from the protozoan Trypanosoma cruzi, is an
important cause of heart failure, stroke, arrhythmia, and sudden death. Traditionally …

Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …

The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs;
benznidazole and nifurtimox. These drugs have some disadvantages, including their …

Fexinidazole Winthrop (hereafter referred to as fexinidazole) is a DNA synthesis inhibitor
developed by the Drugs for Neglected Diseases initiative (DNDi), in collaboration with …

There is an urgent need for new, safer, and effective treatments for the diseases caused by
the protozoan parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. In …

American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …

Chagas disease (CD) is a tropical neglected illness, affecting mainly populations of low
socioeconomic status in Latin America. An estimated 6 to 8 million people worldwide are …

Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic
Chagas disease, and is one of the leading causes of morbidity and death in Latin America …