Antibiotics are recognised as, on occasion, producing psychiatric side effects, most notably
depression and anxiety. Apart from antimicrobial activity, antibiotics have multiple off‐target …

Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Minocycline has anti-inflammatory, antioxidant, and anti-apoptotic properties that explain the
renewed interest in its use as an adjunctive treatment for psychiatric and neurological …

Stressors ranging from psychogenic/social to neurogenic/injury to systemic/microbial can
impact microglial inflammatory processes, but less is known regarding their effects on …

Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-
based antidepressants were the first drugs developed to treat major depressive disorder …

Depression is a common mental disorder, the effective treatment of which remains a
challenging issue worldwide. The clinical pathogenesis of depression has been deeply …

Stress and substance use disorders remain two of the most highly prevalent psychiatric
conditions and are often comorbid. While individually these conditions have a debilitating …

Background As antidepressants commonly used in the clinic have proved to be problematic,
it is urgent to gain an updated understanding of the pathogenesis of depression and find …

We recently reported that reversing the chronic stress-induced decline of microglia in the
dentate gyrus (DG) of the hippocampus by intraperitoneal injection of a low dose of …