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Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury
The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous
system (PNS), is a critical feature in the context of peripheral nerve regeneration following …
system (PNS), is a critical feature in the context of peripheral nerve regeneration following …
The success and failure of the Schwann cell response to nerve injury
KR Jessen, R Mirsky - Frontiers in cellular neuroscience, 2019 - frontiersin.org
The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …
and myelin phenotypes, which are specialized to meet the needs of small and large …
Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves
Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …
specialized for promoting regeneration and repair. These repair cells clear redundant …
Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration
Peripheral nerve injury (PNI), one of the most common concerns following trauma, can result
in a significant loss of sensory or motor function. Restoration of the injured nerves requires a …
in a significant loss of sensory or motor function. Restoration of the injured nerves requires a …
[HTML][HTML] MAPK/ERK pathway as a central regulator in vertebrate organ regeneration
Damage to organs by trauma, infection, diseases, congenital defects, aging, and other
injuries causes organ malfunction and is life-threatening under serious conditions. Some of …
injuries causes organ malfunction and is life-threatening under serious conditions. Some of …
Role of histone modifications in neurogenesis and neurodegenerative disease development
A Zhao, W Xu, R Han, J Wei, Q Yu, M Wang, H Li… - Ageing Research …, 2024 - Elsevier
Progressive neuronal dysfunction and death are key features of neurodegenerative
diseases; therefore, promoting neurogenesis in neurodegenerative diseases is crucial. With …
diseases; therefore, promoting neurogenesis in neurodegenerative diseases is crucial. With …
Advances in the repair of segmental nerve injuries and trends in reconstruction
Despite advances in surgery, the reconstruction of segmental nerve injuries continues to
pose challenges. In this review, current neurobiology regarding regeneration across a nerve …
pose challenges. In this review, current neurobiology regarding regeneration across a nerve …
Insights into the role and potential of Schwann cells for peripheral nerve repair from studies of development and injury
Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …
Schwann cells as orchestrators of nerve repair: implications for tissue regeneration and pathologies
Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …
signaling system to control tissue structure and function. However, following injury …
Neuron-Schwann cell interactions in peripheral nervous system homeostasis, disease, and preclinical treatment
Schwann cells (SCs) have a critical role in the peripheral nervous system. These cells are
able to support axons during homeostasis and after injury. However, mutations in genes …
able to support axons during homeostasis and after injury. However, mutations in genes …