Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

Background The tumor microenvironment (TME) is a critical player in tumor progression,
metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well …

During metastasis, malignant cells escape the primary tumor, intravasate lymphatic vessels,
and reach draining sentinel lymph nodes before they colonize distant organs via the blood …

The lymphatic vascular system has an important role in the regulation of tissue pressure,
immune surveillance and the absorption of dietary fat in the intestine. There is growing …

Lymphatic metastasis is the main prognostic factor for survival of patients with breast cancer
and other epithelial malignancies. Mounting clinical and experimental data suggest that …

The formation of distant metastases is the deadliest phase of cancer progression. Although
numerous studies have identified genes and mechanisms that affect metastasis after tumors …

Preclinical and clinical studies positively correlate the expression of vascular endothelial
growth factor (VEGF)-C in tumors and the incidence of lymph node metastases. However …

The lymphatic vasculature is essential for the maintenance of tissue fluid balance, immune
surveillance, and adsorption fatty acids in the gut. The lymphatic vessels are also crucially …

Metastasis, which commonly uses lymphatics, accounts for much of the mortality associated
with cancer. The vascular endothelial growth factor (VEGF)-C coreceptor, neuropilin-2 …