Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …

Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Telomerase is a key enzyme for cell survival that prevents telomere shortening and the
subsequent cellular senescence that is observed after many rounds of cell division. In …

The majority of common variants associated with common diseases, as well as an unknown
proportion of causal mutations for rare diseases, fall in noncoding regions of the genome …

Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining
telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless …

Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's
lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short …

Over the last decade, extraordinary progress has been made in elucidating the underlying
genetic causes of gliomas. In 2008, our understanding of glioma genetics was …