Cellular senescence and Alzheimer disease: the egg and the chicken scenario
S Saez-Atienzar, E Masliah - Nature Reviews Neuroscience, 2020 - nature.com
Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …
Microglia in Alzheimer disease: well-known targets and new opportunities
AL Hemonnot, J Hua, L Ulmann… - Frontiers in aging …, 2019 - frontiersin.org
Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …
in brain development, and physiology during life and aging. Equipped with a variety of …
Self-organizing 3D human neural tissue derived from induced pluripotent stem cells recapitulate Alzheimer's disease phenotypes
The dismal success rate of clinical trials for Alzheimer's disease (AD) motivates us to
develop model systems of AD pathology that have higher predictive validity. The advent of …
develop model systems of AD pathology that have higher predictive validity. The advent of …
Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology
J Cheng, Y Dong, J Ma, R Pan, Y Liao, X Kong, X Li… - Science …, 2021 - science.org
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world.
Neuronal calcium dysfunction and microglial-mediated neuroinflammation are closely …
Neuronal calcium dysfunction and microglial-mediated neuroinflammation are closely …
The discovery of Alzheimer's disease
H Hippius, G Neundörfer - Dialogues in clinical neuroscience, 2003 - Taylor & Francis
On November 3, 1906, a clinical psychiatrist and neuroanatomist, Alois Alzheimer, reported
“A peculiar severe disease process of the cerebral cortex” to the 37th Meeting of South-West …
“A peculiar severe disease process of the cerebral cortex” to the 37th Meeting of South-West …
Risk factors for Alzheimer's disease
RA Armstrong - Folia neuropathologica, 2019 - termedia.pl
Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD)
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …
What causes Alzheimer's disease?
RA Armstrong - Folia neuropathologica, 2013 - termedia.pl
Since the earliest descriptions of Alzheimer's disease (AD), many theories have been
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …
Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases
Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of
central nervous system (CNS) functionality. It has been shown that neuroinflammation …
central nervous system (CNS) functionality. It has been shown that neuroinflammation …
The molecular bases of Alzheimer's disease and other neurodegenerative disorders
Alzheimer's disease, the cause of one of the most common types of dementia, is a brain
disorder affecting the elderly and is characterized by the formation of two main protein …
disorder affecting the elderly and is characterized by the formation of two main protein …
The case described by Alois Alzheimer in 1911: historical and conceptual perspectives based on the clinical record and neurohistological sections
In 1906, Alzheimer presented the first case of the disease which was later named
Alzheimer's disease by Kraeplin. While the publication on this case in 1907 is only a …
Alzheimer's disease by Kraeplin. While the publication on this case in 1907 is only a …