Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …

Defects in apoptotic cell death can promote cancer and impair responses of malignant cells
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by kee** the cell …

There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …

Cancers remain a major public health problem worldwide, which still require profound
research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are …

Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

Purpose: Patients with acute myeloid leukemia (AML) frequently do not respond to
conventional therapies. Leukemic cell survival and treatment resistance have been …

We are witnessing several revolutionary technological advances in cancer. These
innovations have not only contributed to a growing understanding of the tumor and its …

MYCN is a member of the MYC family of proto-oncogenes. It encodes a transcription factor,
MYCN, involved in the control of fundamental processes during embryonal development …

This paper is in recognition of the 100th birthday of Dr. Herbert Tabor, a true pioneer in the
polyamine field for over 70 years, who served as the editor-in-chief of the Journal of …

Simple Summary Neuroblastoma is one of the most diffuse and the deadliest cancer in
children. While many advances have been made in the last few decades to improve patients' …