Chronic inflammation has been identified as a necessary step to mediate atherosclerosis
and cardiovascular disease and as a relevant stage in the onset and progression of several …

Scope: Flavanols are important polyphenols of the human diet with extensive
demonstrations of their beneficial effects on cardiometabolic health. They contribute to …

Natural biological macromolecules with putative functions of gut microbiota regulation
possess the advantage of improving metabolic syndrome (MS). In this research, we aimed to …

Stimulation of the ubiquitin-proteasome pathway—especially E3 ubiquitin ligases Atrogin-1
and MuRF1—is associated with muscle loss in diabetes. Elevated lipid metabolites impair …

Cocoa powder, derived Theobroma cacao, is a popular food ingredient that is commonly
consumed in chocolate. Epidemiological and human intervention studies have reported that …

Introduction An obesogenic diet, a diet high in saturated fats and sugars, is a risk factor for
the development of multiple obesity-related diseases. In this study, our aim was to evaluate …

Microbial community control is crucial for maintaining homeostasis of the gut–liver axis in
metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that …

Cocoa polyphenols (CPs) have been shown to exhibit hypolipidaemic actions, suggesting
that CPs offer great potential for ameliorating lipid abnormalities. However, the conceivable …

Redox balance, autophagy and apoptosis are main processes involved in the development
of diabetic nephropathy. Epidemiological and animal studies suggest that cocoa might …

Docosahexaenoic acid (DHA) is the most bioactive fatty acid in the brain with well-known
biological effects. Peroxisome proliferator-activated receptors (PPARs) underlie some …