The biomedical research community addresses reproducibility challenges in animal studies
through standardized nomenclature, improved experimental design, transparent reporting …

In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of the
hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing …

Sex disparities in cardiac homeostasis and heart disease are well documented, with
differences attributed to actions of sex hormones. However, studies have indicated sex …

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

Ebola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease
(EVD) in humans. Host genetic variation plays a critical role, yet the identity of host …

Emerging viruses threaten global health, but few experimental models can characterize the
virus and host factors necessary for within-and cross-species transmission. Here, we …

Abstract The HLA-DRB1* 03: 01 allele is a major genetic risk factor in systemic lupus
erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show …

Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …

Infectious diseases have shaped the human population genetic structure, and genetic
variation influences the susceptibility to many viral diseases. However, a variety of …

Genetically diverse mouse populations are powerful tools for characterizing the regulation of
the proteome and its relationship to whole-organism phenotypes. We used mass …