Compressive stresses in cancer: characterization and implications for tumour progression and treatment
JA Linke, LL Munn, RK Jain - Nature Reviews Cancer, 2024 - nature.com
Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …
abnormal physical microenvironment that fuels cancer progression and confers treatment …
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip
Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell …
comprehensive understanding of the developmental trajectories of pancreas-specific cell …
Single-Cell Mechanics: Structural Determinants and Functional Relevance
The mechanical phenotype of a cell determines its ability to deform under force and is
therefore relevant to cellular functions that require changes in cell shape, such as migration …
therefore relevant to cellular functions that require changes in cell shape, such as migration …
Mechanical stress signaling in pancreatic cancer cells triggers p38 MAPK-and JNK-dependent cytoskeleton remodeling and promotes cell migration via Rac1/cdc42 …
Advanced or metastatic pancreatic cancer is highly resistant to existing therapies, and new
treatments are urgently needed to improve patient outcomes. Current studies focus on …
treatments are urgently needed to improve patient outcomes. Current studies focus on …
Cellular shape reinforces niche to stem cell signaling in the small intestine
Niche-derived factors regulate tissue stem cells, but apart from the mechanosensory
pathways, the effect of niche geometry is not well understood. We used organoids and …
pathways, the effect of niche geometry is not well understood. We used organoids and …
MYH10 combines with MYH9 to recruit USP45 by deubiquitinating snail and promotes serous ovarian cancer carcinogenesis, progression, and cisplatin resistance
L Liu, C Chen, P Liu, J Li, Z Pang, J Zhu… - Advanced …, 2023 - Wiley Online Library
The poor prognosis of serous ovarian cancer (SOC) is due to its high invasive capacity and
cisplatin resistance of SOC cells, whereas the molecular mechanisms remain poorly …
cisplatin resistance of SOC cells, whereas the molecular mechanisms remain poorly …
Cell mechanics regulate the migration and invasion of hepatocellular carcinoma cells via JNK signaling
J Wang, B Zhang, X Chen, Y **n, K Li, C Zhang… - Acta biomaterialia, 2024 - Elsevier
Hepatocellular carcinoma (HCC) cells, especially those with metastatic competence, show
reduced stiffness compared to the non-malignant counterparts. However, it is still unclear …
reduced stiffness compared to the non-malignant counterparts. However, it is still unclear …
Heterogeneity, inherent and acquired drug resistance in patient-derived organoid models of primary liver cancer
L **an, P Zhao, X Chen, Z Wei, H Ji, J Zhao, W Liu… - Cellular Oncology, 2022 - Springer
Purpose We aimed to elucidate the applicability of tumor organoids for inherent drug
resistance of primary liver cancer (PLC) and mechanisms of acquired drug resistance …
resistance of primary liver cancer (PLC) and mechanisms of acquired drug resistance …
[HTML][HTML] Precise tuning of cortical contractility regulates cell shape during cytokinesis
The mechanical properties of the actin cortex regulate shape changes during cell division,
cell migration, and tissue morphogenesis. We show that modulation of myosin II (MII) …
cell migration, and tissue morphogenesis. We show that modulation of myosin II (MII) …