IgG4-related disease: an update on pathophysiology and implications for clinical care

CA Perugino, JH Stone - Nature Reviews Rheumatology, 2020 - nature.com
Abstract IgG4-related disease (IgG4-RD) has only existed as a unique disease entity since
2003, yet remarkable progress has already been achieved in describing the essential …

Multi-functional wound dressings based on silicate bioactive materials

C Fan, Q Xu, R Hao, C Wang, Y Que, Y Chen, C Yang… - Biomaterials, 2022 - Elsevier
Most traditional wound dressings passively offer a protective barrier for the wounds, which
lacks the initiative in stimulating tissue regeneration. In addition, cutaneous wound healing …

Inebilizumab for treatment of IgG4-related disease

JH Stone, A Khosroshahi, W Zhang… - … England Journal of …, 2024 - Mass Medical Soc
Background IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-
mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B …

Advances in the diagnosis and management of IgG4 related disease

M Lanzillotta, G Mancuso, E Della-Torre - Bmj, 2020 - bmj.com
IgG4 related disease was recognized as a unified disease entity only 15 years ago.
Awareness of IgG4 related disease has increased worldwide since then, and specialists are …

Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging

C Schmidkonz, S Rauber, A Atzinger… - Annals of the …, 2020 - ard.bmj.com
Objectives To date, there is no valuable tool to assess fibrotic disease activity in humans in
vivo in a non-invasive way. This study aims to uncouple inflammatory from fibrotic disease …

Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: a randomized controlled trial

J Corren, D Larson, MC Altman, RM Segnitz… - Journal of Allergy and …, 2023 - Elsevier
Background Thymic stromal lymphopoietin (TSLP) has been shown to play a central role in
the initiation and persistence of allergic responses. Objective We evaluated whether …

Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa

KR van Straalen, F Ma, PS Tsou, O Plazyo… - The Journal of Clinical …, 2024 - jci.org
Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by
abscesses, nodules, dissecting/draining tunnels, and extensive fibrosis. Here, we integrate …

Extrafollicular IgD− CD27− CXCR5− CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19

H Allard-Chamard, N Kaneko, A Bertocchi, N Sun… - Cell Reports, 2023 - cell.com
Although therapeutic B cell depletion dramatically resolves inflammation in many diseases
in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell …

Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity

TR Kyriakides, HJ Kim, C Zheng, L Harkins… - Biomedical …, 2022 - iopscience.iop.org
Implanted biomaterials elicit a series of distinct immune and repair-like responses that are
collectively known as the foreign body reaction (FBR). These include processes involving …

Clinical phenotypes of IgG4-related disease reflect different prognostic outcomes

M Lanzillotta, C Campochiaro, G Mancuso… - …, 2020 - academic.oup.com
Introduction Four clinical phenotypes of IgG4-related disease (IgG4-RD) have been recently
identified by latent class analysis (LCA): pancreato-biliary (group 1); retroperitoneum/aortitis …