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IgG4-related disease: an update on pathophysiology and implications for clinical care
CA Perugino, JH Stone - Nature Reviews Rheumatology, 2020 - nature.com
Abstract IgG4-related disease (IgG4-RD) has only existed as a unique disease entity since
2003, yet remarkable progress has already been achieved in describing the essential …
2003, yet remarkable progress has already been achieved in describing the essential …
Multi-functional wound dressings based on silicate bioactive materials
C Fan, Q Xu, R Hao, C Wang, Y Que, Y Chen, C Yang… - Biomaterials, 2022 - Elsevier
Most traditional wound dressings passively offer a protective barrier for the wounds, which
lacks the initiative in stimulating tissue regeneration. In addition, cutaneous wound healing …
lacks the initiative in stimulating tissue regeneration. In addition, cutaneous wound healing …
Inebilizumab for treatment of IgG4-related disease
JH Stone, A Khosroshahi, W Zhang… - … England Journal of …, 2024 - Mass Medical Soc
Background IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-
mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B …
mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B …
Advances in the diagnosis and management of IgG4 related disease
IgG4 related disease was recognized as a unified disease entity only 15 years ago.
Awareness of IgG4 related disease has increased worldwide since then, and specialists are …
Awareness of IgG4 related disease has increased worldwide since then, and specialists are …
Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging
Objectives To date, there is no valuable tool to assess fibrotic disease activity in humans in
vivo in a non-invasive way. This study aims to uncouple inflammatory from fibrotic disease …
vivo in a non-invasive way. This study aims to uncouple inflammatory from fibrotic disease …
Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: a randomized controlled trial
Background Thymic stromal lymphopoietin (TSLP) has been shown to play a central role in
the initiation and persistence of allergic responses. Objective We evaluated whether …
the initiation and persistence of allergic responses. Objective We evaluated whether …
Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa
Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by
abscesses, nodules, dissecting/draining tunnels, and extensive fibrosis. Here, we integrate …
abscesses, nodules, dissecting/draining tunnels, and extensive fibrosis. Here, we integrate …
Extrafollicular IgD− CD27− CXCR5− CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19
Although therapeutic B cell depletion dramatically resolves inflammation in many diseases
in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell …
in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell …
Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity
Implanted biomaterials elicit a series of distinct immune and repair-like responses that are
collectively known as the foreign body reaction (FBR). These include processes involving …
collectively known as the foreign body reaction (FBR). These include processes involving …
Clinical phenotypes of IgG4-related disease reflect different prognostic outcomes
Introduction Four clinical phenotypes of IgG4-related disease (IgG4-RD) have been recently
identified by latent class analysis (LCA): pancreato-biliary (group 1); retroperitoneum/aortitis …
identified by latent class analysis (LCA): pancreato-biliary (group 1); retroperitoneum/aortitis …