The role of the microbiome in human aging is important: the microbiome directly impacts
aging through the gastrointestinal system. However, the microbial impact on skin has yet to …

The occurrence of hyperpigmentation or hypopigmentation after inflammation is a common
condition in dermatology and cosmetology. Since the exact mechanism of its occurrence is …

Intermittent intense ultraviolet (UV) exposure represents an important aetiological factor in
the development of malignant melanoma. The ability of UV radiation to cause tumour …

MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous
type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory …

Purpose: In this study, we assessed the specific role of BRAF (V600E) signaling in
modulating the expression of immune regulatory genes in melanoma, in addition to …

Inflammation promotes phenotypic plasticity in melanoma, a source of non-genetic
heterogeneity, but the molecular framework is poorly understood. Here we use functional …

Human skin aging is a natural phenomenon that results from continuous exposure to
intrinsic (time, genetic factors, hormones) as well as extrinsic factors (UV exposure, pollution …

The production of melanin pigments by melanocytes and their quantity, quality, and
distribution play a decisive role in determining human skin, eye, and hair color, and protect …

The aim of this study was to determine whether CD4+ IL‐17A+ Th17 cells infiltrate vitiligo
skin and to investigate whether the proinflammatory cytokines related to Th17 cell influence …