De novo lipogenesis (DNL) is a complex and highly regulated process in which
carbohydrates from circulation are converted into fatty acids that are then used for …

The obesity pandemic continues unabated despite a persistent public health campaign to
decrease energy intake (“eat less”) and increase energy expenditure (“move more”). One …

Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

Metabolic health depends on the brain's ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone …

The melanocortin system provides a conceptual blueprint for the central control of energetic
state. Defined by four principal molecular components—two antagonistically acting ligands …

Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2
diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic …

White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its
activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully …

Summary Melanocortin-4 receptor (MC4R) mutations cause dysregulation of energy
balance and hyperinsulinemia. We have used mouse models to study the physiological …

Although it is a widely held thought that direct hormone action on peripheral tissues is
sufficient to mediate the control of nutrient handling, the role of the central nervous system in …

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated.
Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis …