Immunohistochemistry (IHC) plays an essential role in Pathology. In order to improve
reproducibility and standardization of the results interpretation, IHC quantification methods …

Purpose To update the American Society of Clinical Oncology (ASCO)/College of American
Pathologists (CAP) guideline recommendations for human epidermal growth factor receptor …

Introduction Accurate assessment of estrogen receptor (ER), progesterone receptor (PR),
and Ki-67 is essential in the histopathologic diagnostics of breast cancer. Commercially …

Although immunohistochemistry (IHC) is a popular imaging technique, the quantitative
analysis of IHC images via computer-aided methods is an emerging field that is gaining …

Automatic image segmentation of immunohistologically stained breast tissue sections helps
pathologists to discover the cancer disease earlier. The detection of the real number of …

Purpose To investigate nuclear localized and tyrosine phosphorylated Stat5 (Nuc-pYStat5)
as a marker of prognosis in node-negative breast cancer and as a predictor of response to …

Background and objective This paper presents an improved scheme able to perform
accurate segmentation and classification of cancer nuclei in immunohistochemical (IHC) …

A method is described for the reproducible quantification of biomarker expression, including
biomarker expression in a tissue sample. Methods and systems are described whereby …

Estrogens play essential roles in the progression of mammary and prostatic diseases. The
transcriptional effects of estrogens are transduced by two estrogen receptors, ERα and ERβ …

Context.—There is critical need for standardization of HER2 immunohistochemistry testing in
the clinical laboratory setting. Recently, the American Society of Clinical Oncology and the …