Virus-like particles: fundamentals and biomedical applications

JL Mejía-Méndez, R Vazquez-Duhalt… - International journal of …, 2022 - mdpi.com
Nanotechnology is a fast-evolving field focused on fabricating nanoscale objects for
industrial, cosmetic, and therapeutic applications. Virus-like particles (VLPs) are self …

Virus-like nanoparticles as a novel delivery tool in gene therapy

J Jeevanandam, K Pal, MK Danquah - Biochimie, 2019 - Elsevier
Viruses are considered as natural nanomaterials as they are in the size range of 20–500 nm
with a genetical material either DNA or RNA, which is surrounded by a protein coat capsid …

Protein cargo encapsulation by virus‐like particles: Strategies and applications

D McNeale, N Dashti, LC Cheah… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Viruses and the recombinant protein cages assembled from their structural proteins, known
as virus‐like particles (VLPs), have gained wide interest as tools in biotechnology and …

Confining enzyme clusters in bacteriophage P22 enhances cofactor recycling and stereoselectivity for chiral alcohol synthesis

YQ Zhang, TT Feng, YF Cao, XY Zhang, T Wang… - ACS …, 2021 - ACS Publications
Cofactor recycling is important in the synthesis of chiral alcohols via bioreduction of ketones.
Herein, a carbonyl reductase from Scheffersomyces stipitis (Ss CR) and a glucose …

Nanoreactor-based catalytic systems for therapeutic applications: Principles, strategies, and challenges

D Zhang, D Liu, C Wang, Y Su, X Zhang - Advances in Colloid and Interface …, 2023 - Elsevier
Inspired by natural catalytic compartments, various synthetic compartments that seclude
catalytic reactions have been developed to understand complex multistep biosynthetic …

Packaging of genomic RNA in positive-sense single-stranded RNA viruses: a complex story

M Comas-Garcia - Viruses, 2019 - mdpi.com
The packaging of genomic RNA in positive-sense single-stranded RNA viruses is a key part
of the viral infectious cycle, yet this step is not fully understood. Unlike double-stranded DNA …

Plant viruses and bacteriophage-based reagents for diagnosis and therapy

S Shukla, H Hu, H Cai, SK Chan… - Annual review of …, 2020 - annualreviews.org
Viral nanotechnology exploits the prefabricated nanostructures of viruses, which are already
abundant in nature. With well-defined molecular architectures, viral nanocarriers offer …

[HTML][HTML] Virus-like nanoparticles as enzyme carriers for Enzyme Replacement Therapy (ERT)

O González-Davis, MV Villagrana-Escareño… - Virology, 2023 - Elsevier
Enzyme replacement therapy (ERT) has been used to treat a few of the many existing
diseases which are originated from the lack of, or low enzymatic activity. Exogenous …

Bacteriophage P22 capsid as a pluripotent nanotechnology tool

VA Essus, GS Souza Júnior, GHP Nunes, JS Oliveira… - Viruses, 2023 - mdpi.com
The Salmonella enterica bacteriophage P22 is one of the most promising models for the
development of virus-like particle (VLP) nanocages. It possesses an icosahedral T= 7 …

Biotransporting biocatalytic reactors toward therapeutic nanofactories

T Nishimura, K Akiyoshi - Advanced Science, 2018 - Wiley Online Library
Abstract Drug‐delivery systems (DDSs), in which drug encapsulation in nanoparticles
enables targeted delivery of therapeutic agents and their release at specific disease sites …