Computational deconvolution of transcriptomics data from mixed cell populations
Gene expression analyses of bulk tissues often ignore cell type composition as an important
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …
Transcriptomics for child and adolescent tuberculosis
Tuberculosis (TB) in humans is caused by Mycobacterium tuberculosis (Mtb). It is estimated
that 70 million children (< 15 years) are currently infected with Mtb, with 1.2 million each year …
that 70 million children (< 15 years) are currently infected with Mtb, with 1.2 million each year …
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids
APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer's disease
(AD). To address the underlying mechanism, we develop cerebral organoid models using …
(AD). To address the underlying mechanism, we develop cerebral organoid models using …
Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
Our understanding of kidney disease pathogenesis is limited by an incomplete molecular
characterization of the cell types responsible for the organ's multiple homeostatic functions …
characterization of the cell types responsible for the organ's multiple homeostatic functions …
Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R
Motivation Single-cell RNA sequencing (scRNA-seq) is increasingly used to study gene
expression at the level of individual cells. However, preparing raw sequence data for further …
expression at the level of individual cells. However, preparing raw sequence data for further …
Kidney decellularized extracellular matrix enhanced the vascularization and maturation of human kidney organoids
JW Kim, SA Nam, J Yi, JY Kim, JY Lee… - Advanced …, 2022 - Wiley Online Library
Kidney organoids derived from human pluripotent stem cells (hPSCs) have extensive
potential for disease modelling and regenerative medicine. However, the limited …
potential for disease modelling and regenerative medicine. However, the limited …
Brain cell type specific gene expression and co-expression network architectures
Elucidating brain cell type specific gene expression patterns is critical towards a better
understanding of how cell-cell communications may influence brain functions and …
understanding of how cell-cell communications may influence brain functions and …
The role of m6A/m-RNA methylation in stress response regulation
Summary N 6-methyladenosine (m 6 A) and N 6, 2′-O-dimethyladenosine (m 6 Am) are
abundant mRNA modifications that regulate transcript processing and translation. The role …
abundant mRNA modifications that regulate transcript processing and translation. The role …
Treg cells promote the SREBP1-dependent metabolic fitness of tumor-promoting macrophages via repression of CD8+ T cell-derived interferon-γ
Regulatory T (Treg) cells are crucial for immune homeostasis, but they also contribute to
tumor immune evasion by promoting a suppressive tumor microenvironment (TME). Mice …
tumor immune evasion by promoting a suppressive tumor microenvironment (TME). Mice …
The nuclear receptor ESRRA protects from kidney disease by coupling metabolism and differentiation
Kidney disease is poorly understood because of the organ's cellular diversity. We used
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular …
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular …