T cell receptor (TCR) signaling in health and disease

K Shah, A Al-Haidari, J Sun, JU Kazi - Signal transduction and targeted …, 2021 - nature.com
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

An overview of technical considerations for Western blotting applications to physiological research

JJ Bass, DJ Wilkinson, D Rankin… - … journal of medicine …, 2017 - Wiley Online Library
The applications of Western/immunoblotting (WB) techniques have reached multiple layers
of the scientific community and are now considered routine procedures in the field of …

Biological consequences of vanadium effects on formation of reactive oxygen species and lipid peroxidation

M Aureliano, AL De Sousa-Coelho, CC Dolan… - International Journal of …, 2023 - mdpi.com
Lipid peroxidation (LPO), a process that affects human health, can be induced by exposure
to vanadium salts and compounds. LPO is often exacerbated by oxidation stress, with some …

Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

M Elchebly, P Payette, E Michaliszyn, W Cromlish… - Science, 1999 - science.org
Protein tyrosine phosphatase–1B (PTP-1B) has been implicated in the negative regulation
of insulin signaling. Disruption of the mouse homolog of the gene encoding PTP-1B yielded …

The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds

DC Crans, JJ Smee, E Gaidamauskas… - Chemical reviews, 2004 - ACS Publications
Vanadium is a trace element, which may be beneficial and possibly essential in humans1
but certainly essential for some living organisms. 2r11 Metal ions and thus vanadium ions …

Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments

V Mourino, JP Cattalini… - Journal of the Royal …, 2012 - royalsocietypublishing.org
This article provides an overview on the application of metallic ions in the fields of
regenerative medicine and tissue engineering, focusing on their therapeutic applications …

Anticancer activity of metal complexes: involvement of redox processes

U Jungwirth, CR Kowol, BK Keppler, CG Hartinger… - 2011 - liebertpub.com
Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and …

Hydrogen peroxide as second messenger in lymphocyte activation

M Reth - Nature immunology, 2002 - nature.com
Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular
mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by …

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

SR Lee, KS Kwon, SR Kim, SG Rhee - Journal of Biological Chemistry, 1998 - ASBMB
Stimulation of various cells with growth factors results in a transient increase in the
intracellular concentration of H 2 O 2 that is required for growth factor-induced protein …