Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …

Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons
and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the …

Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/threonine-
protein kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …