[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan
E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
The longitudinal dynamics and natural history of clonal haematopoiesis
Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …
with age, including in the haematopoietic system, where the phenomenon is termed clonal …
[HTML][HTML] Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Some cancers originate from a single mutation event in a single cell. Blood cancers known
as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is …
as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is …
Bayesian inference of ancestral dates on bacterial phylogenetic trees
The sequencing and comparative analysis of a collection of bacterial genomes from a single
species or lineage of interest can lead to key insights into its evolution, ecology or …
species or lineage of interest can lead to key insights into its evolution, ecology or …
Epidemiological inference from pathogen genomes: a review of phylodynamic models and applications
Phylodynamics requires an interdisciplinary understanding of phylogenetics, epidemiology,
and statistical inference. It has also experienced more intense application than ever before …
and statistical inference. It has also experienced more intense application than ever before …
Map** single-cell-resolution cell phylogeny reveals cell population dynamics during organ development
K Liu, S Deng, C Ye, Z Yao, J Wang, H Gong, L Liu… - Nature …, 2021 - nature.com
Map** the cell phylogeny of a complex multicellular organism relies on somatic mutations
accumulated from zygote to adult. Available cell barcoding methods can record about three …
accumulated from zygote to adult. Available cell barcoding methods can record about three …
[HTML][HTML] Tracking hematopoietic stem cells and their progeny using whole-genome sequencing
H Lee-Six, DG Kent - Experimental hematology, 2020 - Elsevier
Highlights•Using acquired somatic mutations as a genetic barcode allows reconstruction of
a stem cell “family tree” of relatedness.•Understanding HSC clonal dynamics is central to …
a stem cell “family tree” of relatedness.•Understanding HSC clonal dynamics is central to …
Modeling the growth and decline of pathogen effective population size provides insight into epidemic dynamics and drivers of antimicrobial resistance
Nonparametric population genetic modeling provides a simple and flexible approach for
studying demographic history and epidemic dynamics using pathogen sequence data …
studying demographic history and epidemic dynamics using pathogen sequence data …
Evolutionary and ecological drivers shape the emergence and extinction of foot-and-mouth disease virus lineages
Livestock farming across the world is constantly threatened by the evolutionary turnover of
foot-and-mouth disease virus (FMDV) strains in endemic systems, the underlying dynamics …
foot-and-mouth disease virus (FMDV) strains in endemic systems, the underlying dynamics …
Distance metrics for ranked evolutionary trees
Genealogical tree modeling is essential for estimating evolutionary parameters in population
genetics and phylogenetics. Recent mathematical results concerning ranked genealogies …
genetics and phylogenetics. Recent mathematical results concerning ranked genealogies …