The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

Physical inactivity is the fourth leading global cause of death and is a major contributor to
metabolic and endocrine diseases. In this review we provide a current update of the past 5 …

INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …

Muscle atrophy and decline in muscle strength appear very rapidly with prolonged disuse or
mechanical unloading after acute hospitalization or experimental bed rest. The current study …

Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal
and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we …

As human space exploration advances to establish a permanent presence beyond the Low
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …

Emerging plans for travel to Mars and other deep space destinations make it critical for us to
understand how spaceflight affects the human brain and behavior. Research over the past …

BACKGROUND AND PURPOSE: Widespread brain structural changes are seen following
extended spaceflight missions. The purpose of this study was to investigate whether these …

Microgravity alters vestibular signaling. In-flight adaptation to altered vestibular afferents is
reflected in post-spaceflight aftereffects, evidenced by declines in vestibularly mediated …

This review includes current and updated information about various ground-based
microgravity models and their impact on the human sensorimotor system. All known models …